Selected Bibliography: NKT Ligands (alpha-C-galactosylceramide)
NKT cells are a unique T lymphocyte sublineage that has been implicated in the regulation of immune responses associated with a broad range of diseases, including autoimmunity, infectious diseases, and cancer. Below you will find a selection of published papers and articles on this topic, many from peer-reviewed journals. To see an abstract of the citation, please click on the link to PubMed.
Bendelac A, Savage PB, Teyton L. The biology of NKT cells.
Annu Rev Immunol. 2007;25:297-336. View Abstract on PubMed
Teng MW, Westwood JA, Darcy PK, Sharkey J, Tsuji M, Franck RW, Porcelli SA, Besra GS, Takeda K, Yagita H, Kershaw MH, Smyth MJ. Combined natural killer T-cell based immunotherapy eradicates established tumors in mice. Cancer Res. 2007 Aug 1;67(15):7495-504. View Abstract on PubMed
Tsuji M. Glycolipids and phospholipids as natural CD1d-binding NKT cell ligands. Cell Mol Life Sci. 2006 Aug;63(16):1889-98. View Abstract on PubMed
Fujii S, Shimizu K, Hemmi H, Fukui M, Bonito AJ, Chen G, Franck RW, Tsuji M, Steinman RM. Glycolipid alpha-C-galactosylceramide is a distinct inducer of dendritic cell function during innate and adaptive immune responses of mice. Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11252-7. View Abstract on PubMed
Godfrey DI, Kronenberg M. Going both ways: immune regulation via CD1d-dependent NKT cells. J Clin Invest. 2004 Nov; 114(10): 1379-88. View Abstract on PubMed
Sandberg JK, Stoddart CA, Brilot F, Jordan KA, Nixon DF Development of innate CD4+ alpha-chain variable gene segment 24 (Valpha24) natural killer T cells in the early human fetal thymus is regulated by IL-7. Proc Natl Acad Sci U S A. 2004 May 4;101(18):7058-63. View Abstract on PubMed
Schmieg J, Yang G, Franck RW, Tsuji M. Superior protection against malaria and melanoma metastases by a C-glycoside analogue of the natural killer T cell ligand alpha-Galactosylceramide. J Exp Med. 2003 Dec 1;198(11):1631-41.
View Abstract on PubMed