Cytheris Scientific Publications/Abstracts/Posters -- HIV
Amanda Leone, Mukta Rohankhedkar, Afam Okoye, Alfred Legasse, Michael K. Axthelm, Francois Villinger, Michael Piatak, Jr., Jeffrey D. Lifson, Brigitte Assouline, Michel Morre, Louis J. Picker and Donald L. Sodora. Increased CD4+ T Cell Levels during IL-7 Administration of Antiretroviral Therapy-Treated Simian Immunodeficiency Virus-Positive Macaques Are Not Dependent on Strong Proliferative Responses. 2010. J. Immunol. Prepublished online Jul 9; doi:10.4049/jimmunol.0902626. View Abstract on Pubmed.
Irini Sereti, Richard M. Dunham, John Spritzler, Evgenia Aga, Michael A. Proschan, Kathy Medvik, Catherine A. Battaglia, Alan L. Landay, Savita Pahwa, Margaret A. Fischl, David M. Asmuth, Allan R. Tenorio, John D. Altman, Lawrence Fox, Susan Moir, Angela Malaspina, Michel Morre, Renaud Buffet, Guido Silvestri and Michael M. Lederman. IL-7 administration drives T cell cycle entry and expansion in HIV-1 infection. 2009. Blood. Prepublished on-line April 20; doi: 10.1182/blood-2008-10-186601. View Abstract on PubMed.
Stephanie Beq, Sandra Rozlan, David Gautier, Raphaelle Parker, Veronique Mersseman, Clementine Schilte, Brigitte Assouline, Iann Rance, Pascal Lavedan, Michel Morre and Remi Cheynier. Injection of Glycosylated Recombinant Simian IL-7 Provokes Rapid and Massive T-cell Homing in Rhesus Macaques. 2009. Blood. Prepublished on-line April 7; doi: 10.1182/blood-2008-11-191288. View Abstract on PubMed.
Yves Levy,Christine Lacabaratz, Laurence Weiss, Jean-Paul Viard, Cecile Goujard, Jean-Daniel Lelièvre, François Boué, Jean-Michel Molina, Christine Rouzioux, Véronique Avettand-Fénoêl, Thérèse Croughs, Stéphanie Beq, Rodolphe Thiébaut, Geneviève Chêne, Michel Morre, and Jean-François Delfraissy Enhanced T cell recovery in HIV-1–infected adults through IL-7 treatment. 2009. J. Clin. Invest. doi:10.1172/JCI38052. View article on JCI website.
CROI 2011
Irini Sereti, Jean-Pierre Routy, Margaret Fischl, Thérèse Croughs, Stéphanie Beq, Michel Morre, M R Boulassel, Michael Yao, William Thompson, and Michael M. Lederman.Recombinant Interleukin-7 (CYT107) Expands CD4 T-cells in Peripheral Blood and Gut Mucosa of Chronically HIV-Infected Immunological Non-Responder Patients. 2011. 18th Conference on Retroviruses and Opportunistic Infections (CROI), Abstract #H-113. View Poster
IAS 2010
Stephanie Beq, Sandra Rozlan, Sandy Pelletier, Bernard Willems, Julie Bruneau, Jean-Daniel Lelievre, Yves Levy, Naglaa H. Shoukry and Rémi Cheynier. Interferon Alpha Therapy Dramatically Alters Thymopoiesis Through Inhibition of IL-7 Secretion in both HCV and HIV-HCV Infected Patients. 2010. 28th International AIDS Conference (IAS) Poster MOPE0165. View Poster
ICAAC 2010
R. Thiebaut, I. Sereti , J. Drylewicz , G. Tambussi , J. Routy , J. Delfraissy , J. Molina , M. Fischl , T. Croughs, R. Sekaly , M. M. Lederman, Y. Levy. Understanding and Predicting the Effect of Interleukin-7 in HIV-1 Infected Patients: A Mathematical Analysis of a Phase I/IIa Study. 50th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC), Poster H-931. View Poster
ICAAC 2009
Y.Levy, I. Sereti, G. Tambussi, J-P Routy, J-F Delfraissy, J-M Molina, M. Fischl, T. Croughs, R-P Sekaly, M. Lederman, 2009. Effects of r-hIL-7 on T Cell Recovery and Thymic Output in HIV-infected Patients Receiving c-ART. Interim Analysis of a Phase I/IIa Multicenter Study. 49th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC). Oral Late-Breaker Presentation, Abstract No. H-1230a. View Presentation
CROI 2010
Thiébaut R, Drylewicz J, Lacabaratz C, Lelievre JD, Chêne G, Beq S, Croughs T, Commenges D, Delfraissy JF, Levy Y. 2010. In vivo quantification of the effect of IL-7 on proliferation, survival and production of CD4+T cells: mathematical analysis of one phase I study in HIV-1 infected patients. 17th Conference on Retroviruses and Opportunistic Infections (CROI), Poster # 389. View Poster
CROI 2008
Lévy Y, Weiss L, Goujard C, Viard JP, Molina JM, Boue F, Lacabaratz C, Rouzioux C, Morre M, and Delfraissy JF. 2008. Sustained Immunological Efficacy of Repeated r-hIL-7 Doses in HIV-1 Infected Patients. Long Term Follow-Up of a Phase I/II Multicenter Study. 15th Conference on Retroviruses and Opportunistic Infections (CROI), Poster #708.
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Leone A, Rohankedkhar M, Okoye A, Assouline B, Morre M, Villinger F, Picker L, and Sodora D. 2008 IL-7 Immunotherapy and T Cell Homeostasis in SIV+ ART-treated Macaques. 15th Conference on Retroviruses and Opportunistic Infections (CROI), Poster #707. View Poster
Beq S, Rozlan S, Gautier D, Parker R, Assouline B, Lavedan P, Morre M and Cheynier R. 2008. Early T cell homing following recombinant simian glycosylated IL-7 injection in Rhesus macaques. 15th Conference on Retroviruses and Opportunistic Infections (CROI), Poster #709. View Poster
CROI 2007
Leone, A, Lehrman G, Jain M, Kaiser P, Picker L, Villinger F, and Sodora D. 2007. HAART Therapy in HIV+ patients increases IL-7 responsiveness of peripheral T cells ex vivo. 14th Conference on Retroviruses and Opportunistic Infections (CROI), Poster #455. View Poster
Lévy Y, Weiss L, Viard JP, Molina J, Goujard C, Boué F, Delluc S, Rouzioux C, Morre M, and Delfraissy J-F. 2007. Repeated r-hIL-7 Doses Improve T-cell Recovery in HIV-1-infected Patients Enrolled in a Phase I/II Multicentric Study. 14th Conference on Retroviruses and Opportunistic Infections (CROI), Oral Abstract #127. View Oral Presentation
Sereti, I, Aga E, Spritzler J, Landay A, Pahwa S, Fischl M, Asmuth D, Tenorio A, Buffet R, Lederman M, and ACTG 5214 team. 2007. rhIL7 in HIV-1-infected Subjects with CD4 T-cell Count >100cells/μL and Viral Load<50,000 copies/mL: Results from a Randomized, Placebo-controlled, Double-blinded Study (ACTG5214). 14th Conference on Retroviruses and Opportunistic Infections (CROI), Oral Abstract #128. View Oral Presentation